HLA typing for transplantation market expected to reach $1,136 million by 2026

“HLA Typing for the Transplant Market | IndustryARC »

The growing number of geriatric patients will contribute to the demand for HLA typing for the transplant market.

the HLA typing for the transplant market is expected to reach $1,136 million by 2026 and is expected to grow at a CAGR of 7.4% during the forecast period 2021-2026. HLA or Human Leukocyte antigen is a common protein antigen inherited from the parental generation. A person would receive six vital HLAs, three from both parents. Antigens were coded as A2, A30, B8, B70, DR3 and DR8. Antigens are the markers present in the body, which helps to distinguish oneself from the other human being. The typing/matching test is rumored to avoid complications such as graft versus host disease, which occurs when the body attempts to eliminate the graft and the immune response or white blood cells are set to counter it as l one of the viruses or bacteria. In addition, major histocompatibility complex due to GVHD, doctors prefer cord blood transplants because the risks decrease by up to 50%. Additionally, transplant diagnostics must be performed to discover any form of virus or immune-acquired diseases, which have the potential to prove fatal to the recipient.

Growing number of organ transplants and associated technology along with increasing geriatric population are some of the factors driving forward HLA typing for the transplant industry during the projected period of 2021-2026 .

HLA Typing for Transplantation Market Segmentation Analysis – By Technology

HLA typing for technology-based transplant market can be further segmented into molecular assay and non-molecular assay technologies. Molecular assay technology has dominated the market in 2020. This is due to the high efficiency and low error rate of the following technology. PCR tests easily help to recognize pathogens or antigens present in the sample, and due to their different sizes (desktop and standing), laboratories and various end users have preferred them over others.

Additionally, molecular testing technology is estimated to be the fastest growing with a CAGR of 7.9% over the forecast period 2021-2026. This is due to recent advancements in the industry after the outbreak of the pandemic and the extensive use of PCR tests to detect the Sars antigen which has forced innovators to look for more durable machines which can be a hybrid module and their would move forward after the pandemic ends. Additionally, PCR technology can provide qualitative and quantitative results within a day or hours of sample collection.

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HLA Typing for Transplantation Market Segmentation Analysis – By End Users

HLA typing for transplantation market based on end users can be further segmented into independent reference laboratories, hospital and transplant center, and research laboratories and academic institutes. The hospital and transplant segment held a dominant market share in 2020. This is due to the multiple specialty hospitals catering to varied demands and having set up in-house testing facilities to facilitate the whole process. For example, Medical City Dallas has become the fastest growing transplant center and has grown approximately 310% in three years.

Additionally, hospital and transplant center is estimated to be the fastest growing with a CAGR of 8.1% over the forecast period 2021-2026. This is due to the increasing number of chronic kidney diseases in the world due to cardiovascular diseases such as diabetes. According to the CDC, 1 in 3 people are at risk of developing such diseases, and there are more than 100,000 people on the waiting list for such transplants. The following would increase the growth of HLA typing for transplant market during the projected period.

HLA Typing for Transplant Market Segmentation Analysis – By Geography

HLA typing for transplant market based on geography can be further segmented into North America, Europe, Asia-Pacific, South America and Rest of the World. The North American market for HLA typing for transplantation held a dominant market share of 37% over others. It is thanks to the rapid deployment of the latest technologies that is reducing deaths. Additionally, government healthcare spending in the region is by far the highest compared to other geographies, which has led to an increase in R&D activities. According to the CDC, the United States spends $11,582 per person, and the share of health spending is close to 17.7% of total GDP.

However, Asia-Pacific offers lucrative opportunities for traders. This is due to growing concerns from government and private bodies to improve medical conditions. To meet these commitments, the region has seen an increase in health spending over the past decade. Countries like Korea and Japan have pioneered health technology and the introduction of IoT in various deployments. Moreover, India has witnessed a 137% increase in healthcare expenditure as compared to 2019. Such developments in the region will contribute to the growth of HLA typing for transplantation market during the projected period of 2021- 2026.

HLA typing for transplant market drivers

The advent of the latest technologies has easily supplanted HLA typing for the transplant market

Using UCB or umbilical cord blood instead of bone marrow helped the market. This is due to the ability of the former to deliver better results than the latter. Moreover, according to various researches, the use of cord blood can reduce the chances of developing GVHD or graft versus host disease to less than 10%, which for bone marrow is 60%. Additionally, cord blood transplants have been found to have a lower ability to develop tumors during life and the risk of viral contamination is low. In addition, the following enables high cell proliferation capacity. The use of HLA typing or matching may advance the use of UCB in unrelated or racial or ethnic minorities whose genetic variations are not yet recorded in the diet. The following advent contributed to the growth of the market.

The growing number of geriatric patients will contribute to the demand for HLA typing

According to the United States Health and Human Services, most transplant patients are over the age of 50 or over 64. This is due to the natural tendency of organs to stop functioning healthily after a sedentary lifestyle and other cardiovascular diseases like diabetes. Moreover, the US CDC predicts a boom in the geriatric population in the coming times and period. According to them, by 2034, young adults and people over 65 will break even and there will be an immediate demand for better and advanced technology to help them with transplants and other ailments.

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HLA Typing for Transplant Market Challenges

Severe GVHD cases have shaken confidence in HLA typing and posed a serious challenge to the market

The incidence of severe or moderate GVHD increased in 7MM. Moreover, epidemiologists have associated various factors that have resulted in a prevalence of the disease of up to 70%. Donor-recipient parity or poor matching of gene antigen and graft source was assigned as the ‘primary reason’. Additionally, GVHD occurs when the body of the patient (recipient) attacks the donor-donated graft, as it identifies it as the potential threat of a foreign substance; cases of death have been recorded during allogeneic stem cell transplants. However, researchers are trying to find the early stages at which the severity of the disease can be lessened.

HLA Typing for Transplant Market Competitive Landscape

Product launches, mergers and acquisitions, joint ventures, and geographic expansions are key strategies adopted by players in the HLA typing for transplantation market. The top 10 HLA typings for companies in the transplant market include:

Thermo Fisher Scientific, Inc.QIAGEN NV, IlluminaCareDx, Inc.Immucor, Inc.Bio-Rad Laboratories, Inc.F. Hoffman-La Roche Ltd.Hologic, Inc.LuminexBiofortuna

HLA typing for transplantation market developments

In November 2019, Thermo Fischer Scientific introduced its “Ion Torrent Genexus System”. The system is a fully integrated next-generation sequencing platform that would automate the workflow of specimens and reporting in a single day. In addition, the company’s goal is to enable local hospitals to adapt to the NGS test function.

In March 2019, QuantuMDx developed a new low-cost sample that allows users/hospitals to use molecular diagnostic technology at low and high levels. Additionally, the device is capable of handling qPCR and end-PCR using a microarray. Additionally, the test guarantees a result within 30 minutes, which will help screen more people.

Key points to remember

Geographically, North America HLA typing for transplantation held a dominant market share in 2020. This is due to the advent and adoption of technologically advanced tools and products that have facilitated the entire process . However, Asia-Pacific offers lucrative opportunities for marketers due to increasing geriatric population and increased spending to achieve better healthcare infrastructure.

A growing geriatric population along with their tendency to have transplants has been recognized as a market-ready driver. However, the associated high costs and chances of developing GVHD have posed a serious challenge to the market.

A detailed analysis of strengths, weaknesses, opportunities and threats will be provided in the HLA typing for transplantation market report.

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